Project at a Glance

Title: Influence of exercise on lung injury induced by ozone and nitrogen dioxide

Principal Investigator / Author(s): Mautz, William J

Contractor: Department of Community and Environmental Medicine, UC Irvine

Contract Number: a2-129-33

Research Program Area: Health & Exposure

Topic Areas: Health Effects of Air Pollution


A ten runway treadmill was enclosed for inhalation toxicologic studies of rodents under exercise exposure to environmental pollutants. The exposure system was lined with sheet stainless steel to minimize scrubbing of charged particles and reactive gases. Average metabolic gas exchange of exercising animals was derived from measurements of inlet or outlet air flow and data from an 02 analyzer in conjunction with either a CO2 . or N2 analyzer. An air flow rate of 400 L.min-1 ensured a response time of 1 min to reach 95% of a step change in metabolic rate and held scrubbing losses of an ozone test atmosphere to less than 2% of treadmill inlet concentration. Gas exchange averaged for 10 rats during incremental exercise up to their highest collective performance was similar to published data for rats tested individually.

For questions regarding this research project, including available data and progress status, contact: Research Division staff at (916) 445-0753

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