Project at a Glance

Title: Sulfate, nitrate inhalation toxicity: First Annual report November 16, 1984 to December 31, 1975

Principal Investigator / Author(s): Phalen, R. F

Contractor: Air Pollution Health Effects Laboratory, Department of Community and Environmental Medicine, UC Irvine

Contract Number: 4-611

Research Program Area: Health & Exposure

Topic Areas: Health Effects of Air Pollution


This first year-end report describes progress made between November 16, 1974 and December 31, 1975. Two major categories of effort are described: a) the start-up of the new health-effects facility (Section II of this report); and b) scientific progress (Sections III, IV and V). Sections on Personnel, status of budget, Results and Discussion and Appendices are also included.

The research is conducted in a 2,200 square foot laboratory building on the North Campus of the University of California, Irvine. The facility, consecutively called SNIF for "Sulfate, Nitrate Inhalation Facility" and IRF for "Inhalation Research Facility" was renamed "Air Pollution Health Effects Laboratory (APHEL). The new name, selected in consultation with University administrative officials, more clearly reflects the current research programs and is hopefully more meaningful to the University community and to the public. The official opening under this name, held May 2, 1975, was attended by University administrators and representatives of the California Air Resources Board. Additional "open-house" ceremonies were held for University personnel and for the general public.

The completed laboratory contains a central exposure room with four main exposure chambers (University of Rochester type; each one cubic meter in volume, Reference: Leach et al., 1958) which are suitable for handling gaseous and particulate atmospheres of varying toxicity including urban and industrial air pollutants, corrosive mists, pathogens and radioactive materials. Small laboratory animals are exposed inside the chambers in any of several modes including: free in wire cages, inside "nose-only" exposure tubes or in body plethysmographs. Larger animals, including human subjects, dogs and pigs can be exposed outside of the chambers to pollutant atmospheres through flexible stainless steel hoses leading to masks: Supporting facilities in the building include a large air purification system, a very complete aerosol laboratory, a gas laboratory, physiology and histopathology laboratories, an animal housing wing, a PDP-11 mini-computer, radiation detection equipment, a small shop, office space, storage space, a small photographic darkroom and a cage washing area. Basic equipping and staffing are complete and a relatively well coordinated research program is in progress. Several problems identified in previous quarterly progress reports have seen satisfactory resolution. A license for use of radioisotopes was obtained in April 1975 (Appendix A), modification to the animal housing wing (sloped and drained flooring, impermeable wall coating, area caging and additional air cleaning equipment) have been made that not only meet the recommendations of the American Association for Accreditation of Laboratory Animal Care but also anticipate future requirements for provision of exercise and animal-to-animal contact.

For questions regarding this research project, including available data and progress status, contact: Research Division staff at (916) 445-0753

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