Project at a Glance

Title: Incidence of respiratory symptoms and chronic diseases in a non-smoking population as a function of long term cumulative exposure to ambient air pollutants (AHSMOG follow-up study)

Principal Investigator / Author(s): Abbey, David E

Contractor: Loma Linda University

Contract Number: A833-057

Research Program Area: Health & Exposure

Topic Areas: Health Effects of Air Pollution


This report studies associations between long term cumulative ambient concentrations of air pollutants in a cohort of 6,340 non-smoking California Seventh-day Adventists. Average annual mean concentrations as well as hours in excess of different thresholds were estimated for each of total suspended particulate (TSP), ozone, and sulfur dioxide (SO,) using monthly interpolations from monitoring stations to zip code centroids from 1967 to 1987. Incidence of the following chronic diseases was ascertained: cancer, definite myocardial infarction (M.I.) (1977-1982); cumulative incidence of definite symptoms of airway obstructive disease, chronic bronchitis, and asthma (1977-1987). All natural cause mortality (1977-1986) was also ascertained. For several thresholds of TSP, statistically significant elevated relative risks were seen for all malignant neoplasms in females, definite symptoms of AOD, chronic bronchitis, and asthma. For one threshold of ozone (10 pphm) elevated relative risks were observed for incidence of respiratory cancers and asthma which approached but not quite achieved the 0.05 level of statistical significance. Increasing severity of asthma symptoms was statistically significantly related to two thresholds of ozone as well as mean concentration. SO, failed to show any statistically significant relationships with the health outcomes studied. Incidence of definite M.I. and all natural cause mortality failed to show statistically significant relationships with any of the pollutants studied.

For questions regarding this research project, including available data and progress status, contact: Research Division staff at (916) 445-0753

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