Project at a Glance

Title: Determination of body burdens for polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in California residents

Principal Investigator / Author(s): Stanley, John S

Contractor: Midwest Research Institute

Contract Number: A6-195-33

Research Program Area: Health & Exposure

Topic Areas: Health Effects of Air Pollution, Toxic Air Contaminants


Determination of body burden levels of polychlorinated dibenzo-p-dioxins and dibentofurans (PCDDs and PCDFs) in residents of California was conducted based on a stratified survey design. Stratification factors included two geographical locations (San Francisco and Los Angeles), three age groups (12 to 34, 35 to 49, and 50 plus years), and sex. A total of 57 adipose tissue specimens were collected across the 12 specific strata. Analysis for the specific 2,3,7,8-substituted isomers was achieved based on high-resolution gas chromatography /high-resolution mass spectrometry (HRGC/HRMS). Detectable levels of PCDDs and PCDFs were measured in all samples with isomer patterns consistent with findings in other studies conducted within the United States, Canada, and Europe. The resulting database demonstrates the prevalence of these compounds in the general California population. The factors (geographic location, age, and sex) considered in the survey design were not statistically significant at the 5% significance level. A questionnaire focused on the lifestyles of participants in the program was conducted to determine residual and occupational information and possible exposure routes to PCDDs and PCDFs. The database provides a reference for comparison in future human monitoring programs.

For questions regarding this research project, including available data and progress status, contact: Research Division staff at (916) 445-0753

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