CARB Research Seminar

This page updated June 11, 2018

Co-exposure to UFPM and O3: Pulmonary C fiber and platelet activation Agreement No: 13-311. Fern Tablin (UC Davis)

Photo of Fern Tablin

Fern Tablin

Photo of Edward Schelegle

Edward Schelegle

Fern Tablin, PhD., VMD and Edward Schelegle MS, PhD., University of California, Davis

June 18, 2018
Cal EPA Headquarters, 1001 "I" Street, Sacramento, CA

Introduction
Presentation
Video
Research Project

Overview

Epidemiologic studies have consistently shown an association between cardiovascular health effects and particulate matter (PM) exposure. Ozone, primarily based on human exposure studies, has been shown to mainly effect the respiratory system with recent research suggesting that ozone exposure may also impact the cardiovascular system. From a public health perspective, very little is known about whether or not there are interactions or synergies between concomitant exposure to ozone and PM and the possible mechanisms involved. This study investigates the physiological effects of co-pollutant exposures of ultrafine particulate matter (UFPM) and ozone in a mature adult rats with and without pre-existing cardiovascular disease. These animal models were chosen because historically it has been shown that older people with pre-existing cardiovascular disease are particularly sensitive to air pollution exposure. Animals were subjected to an acute (6 hour) exposure period to filtered air, ozone, UFPM, or ozone + UFPM followed by a recovery period. Cardiac electrophysiology was monitored during both the exposure and recover periods. Cardiovascular, pulmonary, and hematological samples were then obtained after recovery and analyzed for pathological changes. The results from this analysis along with significance of the findings and next possible research steps will be discussed in today’s seminar.

Speaker Biography

Dr. Tablin received a Bachelor of Arts degree in History from the University of Pennsylvania and a VMD (Veterinarius Medicus Doctorus) and PhD in Anatomy from the University of Pennsylvania as well. She is currently Professor of Anatomy, Physiology and Cell Biology in the School of Veterinary Medicine, UC Davis. Dr. Tablin directs a translational program, using both animal and human studies, which focus on the effects of environmental factors on hemostasis, in particular, platelet activation and the development of a prothrombic state. Her expertise is in platelet physiology, with a particular focus on expression of platelet membrane receptors associated with platelet activation. Dr. Tablin has multiple papers focusing on platelet physiology of domestic animals and animal models in health and disease.

Ph.D., Dr. Schelegle received a Bachelor of Science degree in Animal Physiology from UC Davis, a Master of Arts in Physical Education from UC Davis, and a PhD in Physiology from UC Davis. He is currently Professor of Physiology and Chair of the Department of Anatomy, Physiology and Cell Biology in the School of Veterinary Medicine, UC Davis. He is also a Core Scientist in the Respiratory Diseases Unit at the California National Primate Research Center, UC Davis. He directs a translational program that examines how environmental factors affect human lung health. This translational program includes both animal and human studies. His primary research interest is pulmonary neurophysiology with a focus on the role that lung vagal afferents play in the control of breathing, epithelial injury, inflammation and repair in models of acute and chronic lung injury and/or disease. In addition, he has multiple publications examining the factors that contribute to the exposure-response of ozone in humans


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