CARB Research Seminar

This page updated May 21, 2018

Cardiovascular Effects of Multipollutant Exposure: Mechanisms and Interactions

Photo of presenterMichael T. Kleinman, Ph.D.

Michael T. Kleinman, Ph.D., Environmental Health Sciences, University of California, Irvine

June 01, 2018
Cal EPA Headquarters, 1001 "I" Street, Sacramento, CA

Introduction
Presentation
Video
Research Project

Overview

Fine particulate matter (PM2.5) and ozone (O3) are both common air pollutants known to be associated with heart-related health impacts. However, little is known about whether their effects are altered when they occur together as a mixture. The goal of this study was to determine whether there were significant interactions in the biological responses from concurrent exposures to PM2.5 and O3. This was explored in two ways. First, in the laboratory setting, mice were exposed to concentrated ambient particles (CAPs) or to CAPs administered together with 0.2 ppm O3, which was generated in the laboratory and metered in along with the CAPs. The second approach was to contrast the health outcomes of CAPs exposures to particles formed or aged during periods of relatively high photochemical activity (i.e. spring/summer), which increases ambient O3 concentrations, with outcomes of exposures to fall/winter particles which are associated with lower O3 concentrations. Researchers also examined whether differences in the chemical constituents of the particles might explain possible health outcome differences

Speaker Biography

Michael T. Kleinman, Ph.D., is a Professor and Co-Director of the Air Pollution Health Effects Laboratory in the Department of Medicine at the University of California, Irvine. Prior to joining the faculty at UCI in 1982, he directed the Aerosol Exposure and Analytical Laboratory at Rancho Los Amigos Hospital in Downey, California. Dr. Kleinman's current research has focused on toxicological studies of airborne contaminants using laboratory animals. Professor Kleinman has published more than 100 articles in peer-reviewed journals dealing with the uptake and dosimetry of inhaled pollutants, cardiopulmonary and immunological responses associated with inhalation of PM2.5, health effects of acidic and non-acidic aerosols, and studies of the effects of mixtures of particles with other pollutants such as ozone, formaldehyde, sulfur dioxide, and nitrogen dioxide. Dr. Kleinman's previous studies examined cardiopulmonary effects of concentrated ambient ultrafine, fine and coarse particles using animal models of susceptible human populations. His current studies address the role of organic and inorganic constituents of particulate matter and ozone mixtures in the development or exacerbation of heart disease. Dr. Kleinman has been studying the health effects of exposures to particles and gases found in ambient air for more than 30 years.

Dr. Kleinman is a member of the U.S. EPA Board of Scientific Counselors and is a member of the Science Advisory Panel for the Bay Area Air Quality Management District. Professor Kleinman is Chairman of the State of California's Scientific Review Panel on Toxic Air Contaminants. Professor Kleinman holds a M.S. in Chemistry from the Polytechnic Institute of Brooklyn and a Ph.D. in Environmental Health Sciences from New York University.


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for the seminars please view the Main Seminars web page

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